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George P Studzinski Selected Research

salvin

8/2020Carnosic acid increases sorafenib-induced inhibition of ERK1/2 and STAT3 signaling which contributes to reduced cell proliferation and survival of hepatocellular carcinoma cells.
1/2020Enhancement of sorafenib-mediated death of Hepatocellular carcinoma cells by Carnosic acid and Vitamin D2 analog combination.
1/2018JNK1 as a signaling node in VDR-BRAF induction of cell death in AML.
5/2016Cancer-selective cytotoxic Ca2+ overload in acute myeloid leukemia cells and attenuation of disease progression in mice by synergistically acting polyphenols curcumin and carnosic acid.
1/2012Involvement of microRNA181a in differentiation and cell cycle arrest induced by a plant-derived antioxidant carnosic acid and vitamin D analog doxercalciferol in human leukemia cells.
1/2010Distinct combinatorial effects of the plant polyphenols curcumin, carnosic acid, and silibinin on proliferation and apoptosis in acute myeloid leukemia cells.
1/2008Synergistic antileukemic activity of carnosic acid-rich rosemary extract and the 19-nor Gemini vitamin D analogue in a mouse model of systemic acute myeloid leukemia.
6/2006Cooperative antitumor effects of vitamin D3 derivatives and rosemary preparations in a mouse model of myeloid leukemia.
9/2005Cooperation between antioxidants and 1,25-dihydroxyvitamin D3 in induction of leukemia HL60 cell differentiation through the JNK/AP-1/Egr-1 pathway.
3/2003Carnosic acid potentiates the antioxidant and prodifferentiation effects of 1alpha,25-dihydroxyvitamin D3 in leukemia cells but does not promote elevation of basal levels of intracellular calcium.

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George P Studzinski Research Topics

Disease

27Neoplasms (Cancer)
10/2021 - 03/2003
20Leukemia
11/2016 - 05/2002
20Myeloid Leukemia (Leukemia, Myelocytic)
04/2015 - 03/2003
14Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
01/2018 - 10/2005
5Hypercalcemia (Milk Alkali Syndrome)
09/2010 - 05/2002
3Communicable Diseases (Infectious Diseases)
10/2021 - 12/2014
3Infections
10/2021 - 12/2014
2Hepatocellular Carcinoma (Hepatoma)
08/2020 - 01/2020
2Hematologic Neoplasms (Hematological Malignancy)
05/2016 - 08/2015
1Cytokine Release Syndrome
10/2021
1COVID-19
10/2021
1Inflammation (Inflammations)
10/2021
1Lung Diseases (Lung Disease)
10/2021
1Necrosis
11/2016
1Disease Progression
05/2016
1Tuberculosis (Tuberculoses)
01/2016
1Malaria
01/2016
1Bacterial Infections (Bacterial Infection)
12/2014
1Hypersensitivity (Allergy)
12/2014
1Cardiovascular Diseases (Cardiovascular Disease)
12/2014
1Vitamin D Deficiency
12/2014
1Bone Diseases (Bone Disease)
12/2014
1B-Cell Lymphoma (Lymphoma, B Cell)
12/2014
1Carcinoma (Carcinomatosis)
04/2012
1Myelodysplastic Syndromes (Myelodysplastic Syndrome)
05/2010
1Osteosarcoma (Osteogenic Sarcoma)
01/2009
1Squamous Cell Carcinoma (Epidermoid Carcinoma)
01/2009

Drug/Important Bio-Agent (IBA)

27Vitamin DFDA LinkGeneric
10/2021 - 03/2003
16Calcitriol (Calcijex)FDA LinkGeneric
04/2015 - 05/2002
121,25-dihydroxyvitamin DIBA
10/2011 - 08/2003
10salvinIBA
08/2020 - 03/2003
6PolyphenolsIBA
01/2018 - 06/2006
5AntioxidantsIBA
11/2016 - 03/2003
4Cholecalciferol (Vitamin D3)FDA Link
10/2014 - 05/2002
4Phosphotransferases (Kinase)IBA
10/2014 - 08/2004
4Transcription Factors (Transcription Factor)IBA
07/2014 - 08/2003
3CalciumIBA
04/2012 - 03/2003
2Sorafenib (BAY 43-9006)FDA Link
08/2020 - 01/2020
2Ergocalciferols (Ergocalciferol)FDA LinkGeneric
01/2020 - 01/2018
2Therapeutic UsesIBA
01/2018 - 08/2015
2Cytarabine (Cytosar-U)FDA LinkGeneric
01/2018 - 01/2017
21 alpha-hydroxyergocalciferol (doxercalciferol)FDA Link
01/2018 - 01/2012
2CurcuminIBA
05/2016 - 01/2010
2Calcitriol Receptors (Calcitriol Receptor)IBA
12/2014 - 12/2007
2VitaminsIBA
10/2014 - 08/2003
21 alpha,24-dihydroxyvitamin D3 (Tacalcitol)IBA
07/2012 - 10/2005
2Silybin (Lagosa)IBA
11/2010 - 01/2010
2Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
11/2006 - 08/2003
2JNK Mitogen-Activated Protein KinasesIBA
04/2006 - 08/2003
2CCAAT-Enhancer-Binding Protein-betaIBA
10/2005 - 01/2004
1proto-oncogene protein Spi-1IBA
01/2017
1Proteins (Proteins, Gene)FDA Link
11/2016
1Biological ProductsIBA
05/2016
1AntigensIBA
12/2014
1Granzymes (Granzyme)IBA
12/2014
1BIX 02189IBA
10/2014
1hydroxide ionIBA
10/2014
1XMD 8-92IBA
10/2014
1Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
06/2014
1Tyrosine Kinase InhibitorsIBA
06/2014
11,25-dihydroxyergocalciferolIBA
07/2012
1quinoline-val-asp(OMe)-CH2-OPHIBA
07/2012
1CaspasesIBA
07/2012
1Caspase InhibitorsIBA
07/2012
1Oxidants (Oxidizing Agents)IBA
04/2012
1Histones (Histone)IBA
04/2012
1Messenger RNA (mRNA)IBA
10/2011
1Oncogene Proteins (Oncogene Protein)IBA
05/2011
1MAP Kinase Kinase Kinases (MAP Kinase Kinase Kinase)IBA
07/2010
1nutlin 3IBA
05/2010
1Mitogen-Activated Protein Kinase 9IBA
10/2009
1Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
04/2008
1Salicylic Acid (2 Hydroxybenzoic Acid)FDA LinkGeneric
04/2008
1Indomethacin (Indometacin)FDA LinkGeneric
04/2008
1Pharmaceutical PreparationsIBA
12/2007
1KSR-1 protein kinaseIBA
08/2007
1SteroidsIBA
06/2007
11,25-dihydroxy-16,23-diene vitamin D3IBA
06/2006
1Cyclin-Dependent Kinases (cdk Proteins)IBA
08/2004
1CCAAT-Enhancer-Binding ProteinsIBA
01/2004
1Retinoblastoma ProteinIBA
01/2004
1Hormones (Hormone)IBA
08/2003
1Transcription Factor AP-1 (Transcription Factor AP 1)IBA
08/2003
1Mitogen-Activated Protein KinasesIBA
08/2003
11,25-dihydroxy-5,6-16-ene-vitamin D3IBA
05/2002

Therapy/Procedure

20Therapeutics
01/2020 - 03/2003
5Chemoprevention
01/2009 - 08/2004
3Drug Therapy (Chemotherapy)
01/2017 - 08/2004
1Injections
06/2006